In the past two-three decades, peptides have attracted increasing attention of researchers and pharmaceutical business. Along with the proven biological activity of many individual peptides that are basis for unique pharmaceuticals, the subtle regulatory effect of whole peptide pools was recently discovered. It's studied by separate knowledge area - proteomics that is a logical and functional continuation of genomic research.
Peptides are widely used for creation of medicinal, cosmetic preparations, vaccines (adjuvants, synthetic antigens), immunodiagnostics (peptide chips), targeted transport of drugs and other nanoparticles (theranostics), for scientific purposes (peptide mapping, structure confirmation, peptide probes) etc.
The growing needs of the scientific and pharmaceutical community in peptides cannot be covered by natural sources. Besides this method is rather expensive, it's not able to produce structure modified peptides that required for effect improvement. It may be solved by using chemical synthesis in automatic solid-phase synthesizers that provide the fastest and most economical way to obtain any peptide structure in sufficient quantity, including those that living organisms are not capable to synthesize. Automatic synthesis is indispensable for obtaining long biopolymers of arbitrary structure, optimizing peptide pharmaceuticals, creating mass spectrometric libraries or producing biochips.
Since 2011 year Spectronika represents in Russia the unique technologies of Gyros Protein Technologies (USA) for solid-phase peptide synthesis by the FMOC or BOC methods. During this time we installed about 2 dozen synthesizers and gained a lot of experience in complex equipping of biochemical and synthesical laboratories. Following the purchasing of one unit, some of our customers acquire a second, or even third one over time.
Main advantages of Gyros Protein Technologies peptide synthesizers:
- range of instruments - from training to production models (the scale of synthesis is from 0.005 to 200 mmol);
- parallel synthesis from 1 to 24 different peptides;
- possibility of simultaneous execution of several different programs, inaccessible for microwave and robotic devices;
- rapid optimization and standardization of synthesis protocols;
- patented technology of dosing amino acids and solvents through individual channels;
- absence of mechanical parts in the reagent supply system;
- motion of reagents in inert atmosphere (nitrogen);
- various modes of mixing;
- automatic peptides cleavage from solid phase;
- special options (savings of valuable reagents, patented real-time UV monitoring, infrared or induction heating, automatic cleaning, remote information);
- using of arbitrary reagents, not limiting capabilities of devices only in peptide synthesis.
Together with synthesizer, we are ready supply related reagents (FMOC-protected amino acids, activators and resins manufactured by Gyros Protein Technologies) and other kinds of equipment necessary for peptide isolation, analysis, purification and storage.
